Diosmectite was well tolerated. Secondary efficacy analyses were conducted in the ITT population. If your doctor prescribes loperamide for long-lasting diarrhoea, they will tell you how much to take. The present study was designed to investigate the clinical efficacy and safety of dioctahedral smectite in Chinese patients with chronic functional diarrhoea and to compare this activity to a probiotic preparation. Would love your thoughts, please comment. Although diosmectite has demonstrated efficacy in the treatment of acute watery diarrhoea in children, its efficacy in adults still needs to be assessed. Diarrhea loose, watery and possibly more-frequent bowel movements is a common problem. Book an appointment automatically - Get the personalized health, By clicking the Sign Up button or the submit button, I confirm that I have read and agree to the, Address: 458 Minh Khai, Vinh Tuy Ward, Hai Ba Trung District, Hanoi, Vietnam, Obstetrics & Gynecology and Assisted reproductive technology, Rights and responsibilities of patients and their families, Vinmec Research Institute of Stem Cell and Gene Technology, How to handle when children have diarrhea due to taking antibiotics, Different roles of zinc in immune responses, Treating bowel and urinary disorders with physiotherapy. What isn't absorbed by the intestines continues along the digestive tract and is passed as stool during a bowel movement. The primary objective was to compare the efficacy of diosmectite to that of placebo in adults with acute watery diarrhoea, taking time to recovery as a primary endpoint. The rest of their drug action differs, however. It was therefore planned to compare mean diarrhoea durations using the Wilcoxon's test, which is perfectly adapted to this type of data. The ITT population included randomized patients having taken the study drug at least once together with a primary endpoint that was assessable. Does Smecta stop diarrhea? Sometimes, several doses of activated charcoal are needed to treat severe poisoning. Recalls Certain Pilot COVID-19 At-Home Tests for Potential Bacteria Contamination. The drug is stored up to three years. Smecta is an oral formulation of pharmaceutical clay indicated in the treatment of acute diarrhoea in both adults and children above 2 years old, and the symptomatic treatment of digestive pain and chronic diarrhea in adults. In practice, the daily dosage can be doubled at the beginning of the treatment. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. For acute diarrhea, adults should take 6 sachets per day for 3 days. Of note is that most patients had a recent episode of acute diarrhoea, similar in both groups (median time from first watery stool to treatment onset = 1 [03] day from the 1st watery stool to inclusion (NS)), with at least one associated symptom such as nausea, abdominal pain, or anal irritation in >90% of the patients and a median number of six stools per day before treatment onset. Smecta with diarrhea comes into contact with glycoproteins of mucous tissues and provides increased mucous protection from irritants. Frequent side effects are: constipation, difficulties with defecation, which usually occur after a decrease in the frequency of taking Smecta. This is a relatively unusual treatment option, you can call it an alternative method. Hence, it can be extrapolated that if the primary endpoint variable had been measured from the time of onset of diarrhoea, instead of from the first intake of study drug, the difference between the two groups would still have been the same, that is, 15.2 hours. Download MyVinmec app to make appointments faster and to manage your bookings easily. The good news is, even if you suffer from acute diarrhea, there may be things you can do to help manage it. Drugs and medicines Smecta: instructions for use for children and adults August 20, 2019 Doc Said Editorial 2 Comments Share me! Be carefull though, as Smecta may cause dehydration in your baby. It can only be inferred from these studies that, depending on the modalities of treatment and recovery definition, diosmectite and loperamide can show similar improvements of the duration of acute diarrhoea in adults. Guidelines for adults on self-medication for the treatment of acute diarrhoea. You have acute or chronic diarrhoea and the problem does not disappear within 7 days, Diarrhoea is associated with a high temperature, sudden weight loss or vomiting. In the PP analysis (n = 282), median time to recovery was 54.5 hours [3.7167.3] for the diosmectite group and 68.2 hours [2.2165.0] for the placebo group when tested with Wilcoxon's test (P = .067). Smecta with strong diarrhea also demonstrates the therapeutic effect: the intestinal microflora is normalized, the stool is fixed, nausea and unpleasant sensations in the abdominal region pass. Guidelines for the clinical evaluation of antidiarrheal drugs. Of note is that it was much more constraining than previous trials, which defined recovery as the first nonliquid stool. H. M.-Fortunet and P. Garnier are employees of Ipsen, the developer of diosmectite and owner of Smecta. Over-the-counter anti-diarrheal medications, such as loperamide and bismuth subsalicylate, might help reduce the number of watery bowel movements and control severe symptoms. Smecta can be used as an adsorbent in children of any age, starting from 1 month. Mor J, Bnazet F, Fioramonti J, Droy-Lefaix MT. In addition, the trial data presented here employed a more stringent definition of recovery. Can I mix it to mik instead of water? One of the advantages of the tool is that it acts exclusively in the field of the gastrointestinal tract. Exclusion criteria related to the diarrhoea episode were fever >39C, blood or pus in stools, previous history of acute watery diarrhoea over the past 30 days, dehydration requiring intravenous rehydration, traveller's diarrhoea, history of chronic diarrhoea (three or more loose or watery stools per day for at least 12 weeks, consecutive or not, in the preceding 12 months), and motor diarrhoea defined as urgent, morning postprandial need for defaecation. Secondary efficacy endpoints were time (hours) from the first sachet intake to the last watery stool and, per 12-hour period, number of stools, number of watery stools, percentage of patients having recovered (defined as having achieved the primary efficacy endpoint), and percentage of patients with associated symptoms such as nausea, abdominal pain, and anal irritation. Instructions for use Smecta provides an answer to this question. AEs leading to permanent study medication discontinuation were reported in 3 patients in the diosmectite group (1.7%) and in 3 patients in the placebo group (1.7%). Smecta slows down the absorption of alcohol from the blood, so when drinking alcohol intoxication occurs more slowly. Results. The powdery mass is light with a slight grayish or yellowish tint and a barely perceptible nonspecific or vanilla flavor. Smecta can also be used to treat hangover. Smecta is also not suitable in cases of suspected toxic (non-food poisoning). First, Smecta fills minor defects in the mucous membrane and forms a protective layer on its surface. Nausea during the 24 hours before inclusion was present in 71.7% of the patients in the diosmectite group and 68.7% in the placebo group. Therefore, the concomitant use of other medicinal products is not recommended. Loperamide inhibits release of acetylcholine through activation of receptors, resulting in decreased peristaltic activity.3,4 Furthermore, inhibition of acetylcholine release . So, Smecta is an enterosorbent, and Phosphalugel is not only a sorbent, but also an acid neutralizer, and an astringent preparation. 183 avenue Mohamed V, 1002 Tunis, Tunisia, 2Regional Hospital, Route MornagYasminet, 2013 Ben Arous, Tunisia, 3Tahar Mamouri Regional Hospital, 8000 Nabeul, Tunisia, 4Interior Security Forces Hospital, 2070 La Marsa, Tunisia, 5Charles Nicolle Hospital, Boulevard du 9 avril, 1006 Tunis, Tunisia, 6Ipsen, 65 quai Georges Gorse, 92100 Boulogne-Billancourt, France, 7Univ Lille Nord de France, F-59000 Lille, France. Due to the presence of glucose and saccharose, this medication is contraindicated for patients who are fructose intolerant. Smecta is one of the most effective sorbents. Most cases of diarrhoea get better in 5 to 7 days. Dupont C, Foo JLK, Garnier P, Moore N, Mathiex-Fortunet H, Salazar-Lindo E. Oral diosmectite reduces stool output and diarrhea duration in children with acute watery diarrhea. To get started with moderating, editi Copyright 2023, Meds Safety. You can also contact us! The fact is that the drug slightly reduces intestinal motility. The contents of the sachet must be mixed in half a glass of water before its administration. Side effects when taking the drug conditionally divided into frequently occurring and rare. In pregnancy, the drug is quite possible, but they should not be treated for longer than three days. Together with other drugs aimed at eliminating the cause of the appearance of temperature and diarrhea, the medicine will help to accelerate recovery. All rights reserved. These authors own no shares in Ipsen, and no member of their immediate family is employed by Ipsen. Anal irritation before inclusion was present in 18.1% of the patients in the diosmectite group and 24.5% in the placebo group. Before use read the annotation that came directly to medicines. Drugs in the management of acute diarrhoea in infants and young children. Find our products online on our partners' websites. However, in people who are not prone to constipation, this phenomenon can occur only in the case of taking the drug in too large quantities. The endpoints most frequently used in trials regarding antidiarrhoeal drugs in children and adults are stool volume and time from treatment onset to last liquid or first formed stool [12, 14, 26, 27]. Here are some precautions to use Smecta that you need to be aware of: Smecta acts as an adsorbent and is indicated in the symptomatic treatment of diarrhea. The medicine is prepared immediately before the reception. Then take 3 sachets for another 2 4 days. Vinmec is not responsible for any cases of self-application without a doctor's prescription. The objective of this study was therefore to assess the efficacy of diosmectite on the time to recovery in adults with acute diarrhoea. Temporarily excluded are raw vegetable products, fatty foods, spices, smoked products, semi-finished products, carbonated drinks. The clinical effect of diosmectite has nonetheless been studied in functional diarrhoea [15, 16], radiation-induced diarrhoea [17], irinotecan-induced diarrhoea [18], and AIDS-associated chronic idiopathic diarrhoea [19]. government site. Received 2011 Feb 1; Revised 2011 Mar 29; Accepted 2011 Apr 27. Self-medication is dangerous for your health. By making small changes to your lifestyle - such as knowing which foods to avoid - you may be able to regain control and spend more time feeling like yourself. 4 sachets per day for 3 days, then 2 sachets per day for 4 days, Please click here to refer to package leaflet for more information on Smecta Orange-Vanilla t c hiu qu D ng m sa b ngy nay l vn c nhiu cha m quan tm. Smecta in diarrhea is used between meals. Depending on diarrhoea severity, the daily dose can be doubled (6 sachets) at the start of the treatment. The two treatment groups were well balanced for basic demographic data and disease history. Exceed the proposed dosage should not be allowed. Place for medicines should be inaccessible to children. The use of Smecta above the recommended amount can lead to the development of constipation or the formation of bezoar stone in the stomach. Results of a double-blind randomized, placebo-controlled multicenter study. Accessibility With severe diarrhea, it is important not to overdo it: an adult patient is allowed to take no more than six Smekty sachets a day. So, for heartburn, medicine is best taken after a meal. Treatment compliance was assessed at visit 2 or 3, based on sachet consumption recorded in the patient diary, overall count of used and unused sachets, and answers to questions on study drug compliance. In adults, the treatment does not dispense with rehydration, if this is considered to be necessary. It is necessary to observe the interval between taking the drug and eating about 1-2 hours. Teens over 12 take 6 sachets per day for 3 days. You should also not take medicine in case of intolerance to its components. Note that the numbers in parentheses ([1], [2], etc.) In both groups, the most frequently reported AEs were gastrointestinal disorders. Dehydration occurs when the amount of body fluid lost (through urine, feces, breath, sweat, ) is more than the amount absorbed (drinking water, soup, Berinthepharm c ch nh iu tr trong trng hp tiu chy do nhiu nguyn nhn khc nhau. The median [range] duration of exposure was 4.2 days [0.37.5] in the diosmectite group and 4.2 days [010.1] in the placebo group. It was a powder for oral suspension in a sachet, composed of 1.000g titanium dioxide, 1.181g maltodextrin (Roquette Glucidex IT 38), 0.004g vanillin, 0.007g sodium saccharin, 2.150g glucose monohydrate, and 0.018g caramel colouring E150B. Patients were randomly treated with either diosmectite or placebo. A total of 346 adults with at least three watery stools per day over a period of less than 48 hours were prospectively randomized to diosmectite (6g tid) or placebo during four days. If you're taking Lomotil and your diarrhea doesn't improve within 10 days, let your doctor know. It also adsorbs toxins, bacteria, and rotavirus, preventing their adherence to intestinal membranes. The Gehan-Wilcoxon test was preferred to the Logrank test because of the particular distribution of the events considered and the onset of censures during study followup. Pepto-Bismol, on the other hand . Octreotide does not prevent diarrhea in patients treated with weekly 5-fluorouracil plus high-dose leucovorin. Fendri C, Slim A, Arrouji Z, et al. Patients attended the study centres three times: at screening (patients included in the study began treatment at once), at midstudy (day 4 or 5 after inclusion), and for a concluding examination (day 8 or 9 after inclusion).